My Girls Skin Care MARI-GOLD Hand and foot cream provides comfort for the skin toxicity side effects of chemotherapy, and very dry hands and feet that can become cracked and sensitive due to medications, sports and over-exposure to the elements. Helpful for lessening skin issues related to Hand-foot syndrome (also called palmar-plantar erythrodysesthesia) a side effect of some chemotherapy drugs that can cause redness, swelling and blistering on the palms of the hands and soles of the feet. Allantoin, an extract from the root of the comfrey plant, completes this wonderfully soothing moisture barrier cream to soften and smooth the keratin; a tough inflexible protein found in the epidermis, nails and hair.